Table of Contents
What is the function of glomerular?
The main function of the glomerulus is to filter plasma to produce glomerular filtrate, which passes down the length of the nephron tubule to form urine.
What is the glomerular space?
Bowman’s capsule (or the Bowman capsule, capsula glomeruli, or glomerular capsule) is a cup-like sac at the beginning of the tubular component of a nephron in the mammalian kidney that performs the first step in the filtration of blood to form urine. A glomerulus is enclosed in the sac.
What goes through the glomerulus?
During filtration, blood enters the afferent arteriole and flows into the glomerulus where filterable blood components, such as water and nitrogenous waste, will move towards the inside of the glomerulus, and nonfilterable components, such as cells and serum albumins, will exit via the efferent arteriole.
What happens if GFR is too low?
If GFR is too low, metabolic wastes will not get filtered from the blood into the renal tubules. If GFR is too high, the absorptive capacity of salt and water by the renal tubules becomes overwhelmed. Autoregulation manages these changes in GFR and RBF. There are two mechanisms by which this occurs.
How is glomerulus pressure regulated?
A reduction in the mean arterial pressure tends to decrease the afferent arteriole pressure; however, this is accompanied by an increase in the efferent arteriole pressure, which acts to maintain the glomerular capillary hydrostatic pressure.
What is the structure and function of the glomerulus?
The glomerulus is responsible for blood filtration and is composed of a tuft of capillaries whose endothelial cells are interconnected with specialized renal visceral epithelial cells, called podocytes, and with mesangial cells.
What is the difference between eGFR and GFR?
GFR is Glomerular Filtration Rate and it is a key indicator of renal function. eGFR is estimated GFR and is a mathematically derived entity based on a patient’s serum creatinine level, age, sex and race.
What determines GFR?
Therefore, GFR is usually estimated from the person’s serum creatinine and/or cystatin C level, in combination with demographic factors such as age, race, and gender using an estimating equation. Use serum creatinine with age, gender, and race in the recommended CKD-EPI creatinine equation (2009).